Welcome to our website

Our laboratory is based on an interdisciplinary approach that includes mouse models for hypertension, microsurgery, cardiovascular phenotyping, behavioral phenotypig, vascular function, in vivo and ex vivo imaging, biochemistry, cellular biology and molecular biology.


As part of the Department of Molecular Medicine of "Sapienza" University of Rome, our group is based at Neuromed Institute in Pozzilli (IS), a centre of excellence for Neurological and Neurovascular Diseases, sited in South Italy.


For more informations visit the linked websites:




Featured Publications:


Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, Landolfi A, Selvetella G, Grieco P, Damato A, Franco E, Haase H, Maffei A, Ciraolo E, Fucile S, Frati G, Mazzoni O, Hirsch E, Lembo G.

Cardiovasc Res. 2011 Oct 27. [Epub ahead of print]

Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-α-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload.

Carnevale D, Cifelli G, Mascio G, Madonna M, Sbroggiò M, Perrino C, Persico MG, Frati G, Lembo G.

Circulation. 2011 Sep 20;124(12):1337-50. Epub 2011 Sep 6.

'Alzheimer-like' pathology in a murine model of arterial hypertension.

Carnevale D, Lembo G.

Biochem Soc Trans. 2011 Aug 1;39(4):939-44.  


Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial.

Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox KM, Hennerici MG, Mattle HP, Rothwell PM, de Cordoüe A, Fratacci MD; PERFORM Study Investigators.

Lancet. 2011 Jun 11;377(9782):2013-22. Epub 2011 May 25.


IQGAP1 regulates ERK1/2 and AKT signaling in the heart and sustains functional remodeling upon pressure overload.

Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G.

Cardiovasc Res. 2011 Apr 14. [Epub ahead of print]


A lesson from polycystic ovarian syndrome: untangling the role of renal sympathetic nervous system on hypertension and insulin resistance.

Lembo G, Grassi G.

J Hypertens. 2011 May;29(5):836-7.


Integrating Cardiac PIP(3) and cAMP Signaling through a PKA Anchoring Function of p110γ.

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E.

Mol Cell. 2011 Apr 8;42(1):84-95.


Chronic Type A aortic dissection: could surgical intervention be guided by molecular markers?

Carnevale D, Lembo G, Frati G.

J Cell Mol Med. 2011 Mar 24. doi: 10.1111/j.1582-4934.2011.01314.x. [Epub ahead of print].


Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase {gamma} Activity in Pressure Overload-Induced Cardiac Failure.

Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E.

Circulation. 2011 Feb 1;123(4):391-9.


Role of neuroinflammation in hypertension-induced brain amyloid pathology.

Carnevale D, Mascio G, Ajmone-Cat MA, D'Andrea I, Cifelli G, Madonna M, Cocozza G, Frati A, Carullo P, Carnevale L, Alleva E, Branchi I, Lembo G, Minghetti L.

Neurobiol Aging. 2010 Oct 18. [Epub ahead of print].